Background: Peritoneal Dialysis (PD) is a renal replacement therapy commonly used in patients with end-stage renal disease (ESRD). Automated PD (APD) is more convenient than traditional continuous ambulatory PD (CAPD) because the manual delivery and drainage of dialysate is not required. Oseltamivir is an oral prodrug widely indicated for the treatment of influenza infections. The […]
Tag Archives | 2014
ISoP Lecture 2014: What have models ever done for you?
January 24, 2014
Authors Leon Aarons
Affiliations The University of Manchester
Presentation type Oral
Presenters Leon Aarons
In this talk I will look critically at the role of modelling within drug research. The theme is basically that many people model for modelling sake without thinking what they are doing. Personally I think this gives modelling a bad name and could be dangerous (but probably not). I will go through a number of […]
Estimating the relative potencies of an anticholinergic medicine: A methodological view point
January 24, 2014
Authors Mohammed Saji Salahudeen, Prasad S Nishtala, Stephen B Duffull
Affiliations School of Pharmacy, University of Otago, Dunedin, New Zealand
Presentation type Oral
Presenters Mohammed Saji Salahudeen
Background Older people continue to be prescribed medicines with anticholinergic properties and are at an increased risk of experiencing adverse events with these medicines.1 Exposure to 1 or more medicines with anticholinergic properties is termed anticholinergic burden.2 Tools to quantify anticholinergic burden have been developed, but the major drawbacks of these tools are the limited […]
Development of a criterion to quantify forgiveness
January 24, 2014
Authors Piyanan Assawasuwannakit, Rhiannon Braund, Stephen B Duffull
Affiliations School of Pharmacy, University of Otago, Dunedin, New Zealand
Presentation type Oral
Presenters Piyanan Assawasuwannakit
Background: A variety of patterns of imperfect adherence have been reported including deviations in timing of doses as well as non-consecutive missed doses and drug holidays [1]. Forgiveness is a drug specific property that arises from the relationship of the duration of action and the dose interval of the drug. When the duration of action […]
Population pharmacokinetic model for D-β-Hydroxybutyrate following ketone monoester ingestion
January 24, 2014
Authors Vittal Shivva (1), Pete Cox (2), Kieran Clarke (2), Ian G Tucker (1), Stephen B Duffull (1)
Affiliations 1. School of Pharmacy, University of Otago, Dunedin, New Zealand 2. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Presentation type Oral
Presenters Vittal Shivva
Background: Ketone bodies, the evolutionary response to starvation in humans, are produced in the liver from fatty acids in response to low blood glucose and insulin, and used by the body as fuels. Ketogenic diets have long been used to treat intractable paediatric epilepsy, with therapeutic evidence for ketosis in other neurodegenerative disorders such as […]
Simplification of a pharmacokinetic model for red blood cell methotrexate disposition
January 24, 2014
Authors Shan Pan (1), Julia Korell (2), Lisa Stamp (3), Stephen Duffull (1)
Affiliations 1. School of Pharmacy, University of Otago, Dunedin, New Zealand. 2. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. 3. Department of Medicine, University of Otago, Christchurch, New Zealand.
Presentation type Oral
Presenters Shan Pan
Background: Methotrexate (MTX, MTXGlu1) is the gold standard treatment of rheumatoid arthritis. The time course of clinical outcomes is difficult to predict after commencing oral or subcutaneous MTX treatment. A 9-compartment pharmacokinetic (PK) model is available for describing the time course of the concentrations of MTXGlu1 and its polyglutamated metabolites (MTXGlu2-5) in red blood cells […]