This submission belongs to the symposium “Pharmacometric approaches in malaria research”. Background: Ivermectin is an antiparasitic drug, which has been used in human and animals for decades. Mass ivermectin treatment in livestock has been suggested as a novel malaria vector control method, as ivermectin-treated hosts are lethal to blood-feeding Anopheles mosquitoes. A long-acting ivermectin formulation […]
Author: Piyanan Assawasuwannakit
Application of relative forgiveness using clinically observed adherence profiles
Background: The circumstance of how sensitive therapeutic success is under imperfect adherence is driven by the property known as forgiveness. We have previously developed a relative forgiveness (RF) criterion [1]. The relative forgiveness criterion can also be used to quantify an RF of each patient given their own drug taking behaviour. Aim: To evaluate the […]
Population pharmacokinetic and pharmacodynamic properties of OZ439 in healthy volunteers and patients with falciparum and vivax malaria
Background: Increased deployment of artemisinin-based combination therapies (ACTs) has been an important contributor to the recent reductions in malaria, but control and elimination goals are now threatened by the emergence of artemisinin resistance in the Greater Mekong sub-region [1]. New drugs with efficacy and safety profiles which are comparable to the ACTs are needed. OZ439 […]
Development of a criterion to quantify forgiveness
Background: A variety of patterns of imperfect adherence have been reported including deviations in timing of doses as well as non-consecutive missed doses and drug holidays [1]. Forgiveness is a drug specific property that arises from the relationship of the duration of action and the dose interval of the drug. When the duration of action […]