Background: The circumstance of how sensitive therapeutic success is under imperfect adherence is driven by the property known as forgiveness. We have previously developed a relative forgiveness (RF) criterion [1]. The relative forgiveness criterion can also be used to quantify an RF of each patient given their own drug taking behaviour. Aim: To evaluate the […]
Piyanan Assawasuwannakit
- PAGANZ Inc Society Member
- Uppsala University
Author Archive | Piyanan Assawasuwannakit
Population pharmacokinetic and pharmacodynamic properties of OZ439 in healthy volunteers and patients with falciparum and vivax malaria
January 24, 2017
Authors Piyanan Assawasuwannakit (1), Sasithon Pukrittayakamee (2), François Nosten (1,3,4), Stephan Chalon (5), Paul van Giersbergen (6), Christoph Siethoff (7), Nathalie Gobeau (5), Jörg Möhrle (5), Nicholas White (1,4), Joel Tarning (1,4)
Affiliations 1. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 2. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 3. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Tak, Thailand, 4. Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK, 5. Medicines for Malaria Venture, Geneva, Switzerland, 6. Van Giersbergen Consulting, Wuenheim, France, 7. Swiss BioQuant, Reinach, Switzerland
Presentation type Oral
Presenters Piyanan Assawasuwannakit
Background: Increased deployment of artemisinin-based combination therapies (ACTs) has been an important contributor to the recent reductions in malaria, but control and elimination goals are now threatened by the emergence of artemisinin resistance in the Greater Mekong sub-region [1]. New drugs with efficacy and safety profiles which are comparable to the ACTs are needed. OZ439 […]
Development of a criterion to quantify forgiveness
January 24, 2014
Authors Piyanan Assawasuwannakit, Rhiannon Braund, Stephen B Duffull
Affiliations School of Pharmacy, University of Otago, Dunedin, New Zealand
Presentation type Oral
Presenters Piyanan Assawasuwannakit
Background: A variety of patterns of imperfect adherence have been reported including deviations in timing of doses as well as non-consecutive missed doses and drug holidays [1]. Forgiveness is a drug specific property that arises from the relationship of the duration of action and the dose interval of the drug. When the duration of action […]