Application of relative forgiveness using clinically observed adherence profiles

Background: The circumstance of how sensitive therapeutic success is under imperfect adherence is driven by the property known as forgiveness. We have previously developed a relative forgiveness (RF) criterion [1]. The relative forgiveness criterion can also be used to quantify an RF of each patient given their own drug taking behaviour. Aim: To evaluate the […]

Population pharmacokinetic and pharmacodynamic properties of OZ439 in healthy volunteers and patients with falciparum and vivax malaria

Background: Increased deployment of artemisinin-based combination therapies (ACTs) has been an important contributor to the recent reductions in malaria, but control and elimination goals are now threatened by the emergence of artemisinin resistance in the Greater Mekong sub-region [1]. New drugs with efficacy and safety profiles which are comparable to the ACTs are needed. OZ439 […]