The Population Analysis Workshops (PAWs) and the PAGANZ Scientific Program will be held at Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Melbourne, Victoria, Australia. Please note, this meeting will be held at the Parkville campus, Monash University, not the Clayton Campus (which is 25 km away).
A detailed map of the Campus is available here. When you arrive, please record your attendance and pick up a name badge at the registration desk.
Please note that this year we will be running both PAWS as Bring Your Own Device (BYOD)
Attendees of the Beginners PAWS will require their own working installation of NONMEM. Meeting attendees of both PAWS will be sent an email containing a link to all PAWS material, including access to NONMEM installation files and a temporary license associated with the meeting.
Social Events
| Wednesday 14th February 2024 | |
| 1830 | Student Social function: Where: The Oxford Scholar Hotel Time: 6pm; with trivia starting at 6:30pm Registration: https://forms.gle/RsuHuNDKeFY2JQS6A |
| Thursday 15th February, 2024 | |
| 1800 | PAGANZ Dinner: Hotel Railway, 291 Albert St, Brunswick |
Population Analysis Workshops (PAWs)
Beginners PAWs
Coordinator: Jacqueline Hannam (University of Auckland) and Shaun Kumar (Parexel)
Wednesday 14th February 2024
| 0830 | Registration and coffee | Registration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1) Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1) |
| 0900 | Introduction to population methods | Cossar Hall Tutorial Room 1, Ground Floor, Sissons Building (Bldg 1) |
| 1000 | Morning tea | |
| 1030 | Hands on with NONMEM I: Residual variance models | |
| 1200 | Lunch | |
| 1300 | Building structural models | |
| 1500 | Afternoon tea | |
| 1530 | Building covariate models | |
| 1700 | Close |
Thursday 15th February, 2023
| 0830 | Registration and coffee | Registration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1) Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1) |
| 0900 | Hands on with NONMEM II: Covariate models | Cossar hall Tutorial Room 1, Ground Floor, Sissons Building (Bldg 1) |
| 1000 | Morning tea | |
| 1030 | Critical appraisal and discussion | |
| 1200 | Lunch |
Intermediate PAWs
Wednesday 14th February 2024
Pumas – 1 day
Coordinators: Mohamed Tarek, Pumas-AI.
For this workshop there will be a mixture of theory and hands on throughout the day.
| 0830 | Registration and coffee | Registration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1) Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1) |
| 0900 | Setting up and introduction to Pumas cloud | Professional Practice Space (PPS) 1 and 2, First Floor, Scott Building (Bldg 2) |
| 1000 | Morning tea | |
| 1030 | Pumas model building, data reading and estimation workflow | |
| 1200 | Lunch | |
| 1300 | Uncertainty quantification, simulation, and dose selection | |
| 1500 | Afternoon tea | |
| 1530 | Joint time to event and tumour size model | |
| 1700 | Close |
Thursday 15th February, 2024
pyDarwin – 1/2 day
Coordinators: Mark Sale and Keith Nieforth, Certara
*Please note earlier start time
| 0800 | Registration and coffee | Registration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1) Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1) |
| 0830* | Overview of machine learning model selection | Collaborative Learning Space (CLS) 1-3, first floor, Scott Building (Bldg 2) |
| 1000 | Morning tea | |
| 1030 | Hands on pyDarwin / Hands on Pirana with Darwin | |
| 1200 | Lunch |
PAGANZ Annual Scientific Meeting
Cossar Hall, Ground Floor, Sissons Building (Bldg 1)
Thursday 15th February, 2024
| 1300-1305 h | Welcome to the PAGANZ Scientific meeting | Cornelia Landersdorfer |
| 1305-1400 h | ISoP Lecture “How Pharmacometrics Accelerates Drug Development” | Joga Gobburu, PhD, MBA, Director, Center for Translational Medicine University of Maryland School of Pharmacy |
| 1400-1530 h | Focus on Monash Chair: Jacqueline Hannam | |
| 1400-1425 | Antibiotic PK/PD: from traditional indices towards model-informed personalised dosing | Cornelia Landersdorfer |
| 1425-1450 | Incorporating ‘omics with PK/PD modelling: examples from in vitro hollow fibre infection models | Jess Tait |
| 1450-1510 | Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia | Sam Mostafa |
| 1510-1530 | Anakinra Pilot – designing a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants | Carl Kirkpatrick |
| 1530-1600 h | Afternoon tea + posters* | Cossar Hall, Ground Floor, Sissons Building (Bldg 1) Poster Presenters: Hyo-jeong Ryu Yu-Wei Lin Ali Taheri Austin Yue Feng Tan Kevin Winardi |
| 1600-1700 h | PAGANZ Annual General Meeting | Jacqueline Hannam |
| 1800 h | PAGANZ Dinner: Hotel Railway, 291 Albert St, Brunswick |
Friday 16th February, 2024
| 0830-0900 h | Registration and coffee | |
| 0900-1020 h | Free oral presentations 1: Paediatrics Chair: Dominika Fuhs | |
| 0900-0920 h | Serum ganciclovir drug exposure in children receiving standard ganciclovir and valganciclovir dosing | Wenyu Yang |
| 0920-0940 h | Pharmacokinetics of tobramycin in children with cystic fibrosis | Kiera Harwood |
| 0940-1000 h | Analytical and non-analytical variation may lead to inappropriate antimicrobial dosing in neonates: an in silico study | Thi Nguyen |
| 1000-1020 h | Population Pharmacokinetics of Piperacillin-Tazobactam in Children’s Plasma and Cerebrospinal Fluid Across a Wide Spectrum of Childhood Ages | Wenyu Yang |
| 1020-1040 h | Morning tea + posters | |
| 1040-1200 h | Free oral presentations 2: Innovation and methodology Chair: Shaun Kumar | |
| 1040-1100 h | Methodologically appropriate evaluation of continuous BMI as a clinical predictor of chemoimmunotherapy efficacy in advanced non-small cell lung cancer | Lee Li |
| 1100-1120 h | Machine learning for enhanced survival prediction from tumour growth inhibition data | Natalie Parent |
| 1120-1140 h | PyDarwin Designer, a prototype, user friendly interface to pyDarwin for machine learning based model selection. | Mark Sale |
| 1140-1200 h | A workflow for resolving model internal consistency in use-reuse settings (aka repairing unstable models) | Stephen Duffull |
| 1200-1220 h | The identifiability of a turnover model for allopurinol urate-lowering effect | Dan Wright |
| 1220-1300 h | Lunch | |
| 1300-1430 h | Free oral presentations 3: Chairs: Siobhonne Breen, Alice Terrill | |
| 1300-1320 h | Evidence based optimal dosing of intravenous artesunate in children with severe falciparum malaria | Julie Simpson |
| 1320-1340 h | Mechanistic Modelling of Gastric pH-Dependent Drug-Drug Interactions | Yan Yan Yeap |
| 1340-1400 h | Mechanism-based modelling of the response from hypermutable cystic fibrosis Pseudomonas aeruginosa isolates to inhaled aztreonam and tobramycin dosing regimens simulated in a dynamic biofilm model | Siobhonne Breen |
| 1400-1420 h | A population pharmacokinetic model of SC insulin therapy for hyperglycemia during acute ischemic stroke among patients with pre-existing diabetes | Karam Alali |
| 1420-1440 h | Effect of ciprofloxacin against Pseudomonas aeruginosa with different resistance mechanisms can be predicted with mechanism-based mathematical modelling where using PK/PD indices fails | Alice Terrill |
| 1440-1445 h | Student prize presentations and meeting close | Cornelia Landersdorfer |
With thanks to our sponsors!
