Background Complex system models may need to be simplified into simpler structures for many practical applications. Proper lumping is a simplification method that merges the original states into fewer pseudo states to produce a reduced system [1]. Recently a proper lumping technique has been used for the simplification of a large-scale systems pharmacological model [2]. […]
Shan Pan
- PAGANZ Inc Society Member
- Guy's and Thomas' NHS Foundation Trust
Author Archive | Shan Pan
Simplification of a pharmacokinetic model for red blood cell methotrexate disposition
January 24, 2014
Authors Shan Pan (1), Julia Korell (2), Lisa Stamp (3), Stephen Duffull (1)
Affiliations 1. School of Pharmacy, University of Otago, Dunedin, New Zealand. 2. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. 3. Department of Medicine, University of Otago, Christchurch, New Zealand.
Presentation type Oral
Presenters Shan Pan
Background: Methotrexate (MTX, MTXGlu1) is the gold standard treatment of rheumatoid arthritis. The time course of clinical outcomes is difficult to predict after commencing oral or subcutaneous MTX treatment. A 9-compartment pharmacokinetic (PK) model is available for describing the time course of the concentrations of MTXGlu1 and its polyglutamated metabolites (MTXGlu2-5) in red blood cells […]
Relating intracellular methotrexate polyglutamate concentrations in red blood cells with clinical response in rheumatoid arthritis
January 30, 2013
Authors Shan Pan (1), Julia Korell (1), Lisa Stamp (2), Stephen Duffull (1)
Affiliations 1. School of Pharmacy, University of Otago, Dunedin, New Zealand. 2. Department of Medicine, University of Otago, Christchurch, New Zealand.
Presentation type Poster
Presenters Shan Pan
Background: Methotrexate (MTX) is used as the gold standard treatment of rheumatoid arthritis (RA). However, the required dose of MTX to achieve the desired clinical outcome varies widely between individuals and is difficult to predict. MTX plasma concentrations have not proven useful as a predictor for MTX treatment outcomes in RA [1]. It has been […]