Program for Population Approach Workshops

Beginners (6th and 7th of Feburary)

Time Event Speaker
Monday (6th)
0800-0830 Registration and Coffee
0830-1030 Introduction to population methods Carl Kirkpatrick
1030-1100 Morning tea
1100-1230 Hands on with NONMEM Kashyap Patel
1230-1330 Lunch
1330-1530 Building Models Kashyap Patel
1530-1600 Afternoon Tea
1600-1730 Covariate Models Carl Kirkpatrick
Tuesday (7th)
0830-1030 Hands on with NONMEM II Kashyap Patel
1030-1100 Morning Tea
1100-1230 Critical Appraisal and Discussion Carl Kirkpatrick/Kashyap Patel
1230-1330 Lunch
1330 PAGANZ scientific program begins

Intermediate Workshop (6th and 7th February)

Time Event Speaker
Monday (6th)
0800-0830 Registration and Coffee
0830-0900 Transformations – General Martin Bergstrand/Ron Keizer
0900-0945 Transformations of parameter distributions Martin Bergstrand/Ron Keizer
0945-1030 Parameter transformations (NONMEM-based) (Hands On) Martin Bergstrand/Ron Keizer
1030-1100 Morning tea
1100-1145 Transformations of residual error distributions Martin Bergstrand/Ron Keizer
1145-1230 Residual Error transformations (NONMEM-based) (Hands On) Martin Bergstrand/Ron Keizer
1230-1330 Lunch
1330-1415 What does Clinical Trial Simulation (CTS) try to do? Diane Mould
1415-1530 Using NONMEM for simulation (basic ideas) (Hands on) Nick Holford
1530-1600 Afternoon tea
1600-1645 Using Pharsight Clinical Trial Simulator for CTS Nick Holford
1645-1730 Adaptive Simulation (Hands on) Diane Mould
Tuesday (7th)
0830-0930 General principles of PK/PD Modelling of anti-infectives Alan Forrest/Jurgen Bulitta
0930-0945 Questions and Answers Alan Forrest/Jurgen Bulitta
0945-1030 Population PD modelling of bacterial growth and killing (Hands On) Alan Forrest/Jurgen Bulitta
1030-1100 Morning Tea
1100-1130 Mechanism-based modelling to maximize killing and prevent resistance Alan Forrest/Jurgen Bulitta
1130-1140 Questions and Answers Alan Forrest/Jurgen Bulitta
1140-1230 Modeling of bacterial regrowth due to emergence of resistance Alan Forrest/Jurgen Bulitta
1230-1330 Lunch
1330 PAGANZ scientific program begins

PAGANZ Program – All sessions will be held in Cossar Hall

Tuesday (7th) Focus on Melbourne – Carl Kirkpatrick (Chair) Speaker
1330-1335 Welcome from the Dean Bill Charman
1335-1405 Treatment of malaria: from drug discovery to optimisation of current therapies Julie Simpson
1405-1435 Sue Charman
1435-1505 Joel Tarning
1505-1530 Afternoon Tea
Free Oral Presentations- Bruce Green  (Chair)
1530-1545 What is the best dosing regimen for allopurinol in patients with renal impairment Dan Wright
1545-1600 The pharmacokinetic profile of intravenous paracetamol in adult patients undergoing major adbominal surgery: a population analysis Katie Owens
1600-1615 Assessment of vancomycin dosing regimens in Intensive Care Unit patients with impaired renal function Ana Saiao
1615-1630 NextDose – A web based collaborative tool for dose individualisation Nick Holford
1630-1645 Evaluation of a Bayesian dose-individualisation method for enoxaparin Hesham Al-Sallami
1645-1700 A clinical trial incident: Why simple PK is sometimes not so simple Areej Turkistani
1700-1730 Annual General Meeting
Wednesday (8th)
0800-0830 Registration and Coffee
Free Oral presentations- Stephen Duffull (Chair)
0830-0845 Pharmacokinetics of high-dose methotrexate in children with cancer: a mechanism-based evaluation of clearance prediction Sarapee Hirankarn
0845-0900 What is the between cycle variability in methotrexate clearance? Nick Holford
0900-0915 Population pharmacokinetic analysis of ropivacaine and its metabolite PPX from pooled data in neonates, infants and children Leon Aarons
0915-0930 A model for maturation of milrinone clearance from prematurity to adulthood Anita Sumpter
0930-0945 Paracetamol and diclofenac additive effects after tonsillectomy Jacqui Hannam
0945-1000 A model for fat free mass in humans from very premature neonates to young adults Anita Sumpter
1000-1030 Morning tea
Focus on Melbourne  – Julie Simpson (Chair)
1030-1050 Mechanism-based population modelling of dihydroartemisinin pharmacodynamics in murine malaria Kashyap Patel
1050-1110 Population modelling of vildagliptin as an inhibitor and substrate of dipeptidylpeptidase IV Cornelia Landersdorfer
1110-1130 Mechanism-based modelling of antibiotics to optimally cure patients and prevent resistance: progress, gaps and future perspectives Jurgen Bulitta
Free Oral Presentations – Nick Holford (chair) 
1130-1145 Pharmacokinetics of methotrexate in red blood cells Julia Korell
1145-1200 Development and application of a pharmacokinetic model for the glycation of albumin Stephen Duffull
1200-1215 Dose correction for the Michaelis-Menten approximation of the target-mediated drug disposition model Wojciech Krzyzanski
1215-1230 Mechanism-based modeling of antibiotic combinations Rachel Soon
1230-1330 Lunch – with Posters 
Free Oral Presentations  –  Carl Kirkpatrick  (Chair)
1330-1345 Adaptive PD-Optimal design of a pilot study for a clotting time test for enoxaparin Abhishek Gulati
1345-1400 Optimal designs for pharmacokinetic-pharmacodynamic studies of dihydroartemisinin following oral artesunate Kris Jamsen
1400-1415 A reduction in between subject variability is not required when adding a new covariate Chakradhar Lagishetty
1415-1430 Optimal designs for a pharmacominetic study of inhaled fentanyl in children Aaron Basing
1430-1500 Afternoon tea, Presentation of the Nick Holford student prize, close of meeting Carl Kirkpatrick (Chair)

Poster Presentations

Title Presenter
Which matrix is the most reliable to judge the inclusion of covariates: reduction of unexplained parameter variability, increase in explained parameter variability or change in OFV? Stefanie Hennig
Prediction correction: quick fix for VPC misdiagnosis in a tacrolimus popPK model Troels K Bergmann