Brisbane 2000


31 January 2000 – 2 February 2000

MONDAY, January 31

PAGANZ (I)  Room 309, Steele Building, School of Pharmacy, University of Queensland, St Lucia.
08:30 – 08:45
Welcome and introductions (Bruce Charles)

08:45 – 09:15
Background, rationale for population approaches; development and current status of  NONMEM (Nick Holford)

9:15 – 09:30
Discussion and questions

09:30 – 10:00
Applications: Covariate models (Nick Holford)

10:00 – 10:30
Discussion and questions

10:30 – 11:00
Morning tea

11:00 – 12:15
Prof Roger Jelliffe, USC Laboratory of Applied Pharmacokinetics, California, USA
Nonparametric Population Models – Strengths and Weaknesses and Contribution to Optimal Dosage Requirements

12:15 – 13:00
Discussion and questions

13:00 – 14:00
Lunch (UQ Staff Club)

PAWS (I)  Computer Laboratory, UQ Biological Sciences Library (Ground floor)

14:00 – 17:00  (Afternoon Tea 15:30)

Development of a population model from first principles using a guided, hands-on approach


17:00 – 18:00

Drinks (UQ Staff Club)


TUESDAY, February 1


PAWS (II)   Computer Laboratory, Biological Sciences Library

09:00 – 12:00 (Morning Tea 10:30)

Case study in population modelling. Data provided to users who will develop population model(s)


12:00 – 12:30

Discussion of case study


12:30 – 13:30

Lunch (UQ Staff Club)



PAGANZ (II) Room 309, Steele Building, School of Pharmacy

13:30 – 15:00

Open discussion – Hot topics, troubleshooting, controversies


15:00 – 15:30

Afternoon tea


15:30 – 17:30

Individual oral presentations: 10-15 min + 5-10 min discussion


17:30 – 18:30

Drinks (UQ Staff Club)



CityCat from UQ to Southbank for dinner



WEDNESDAY, February 2


PAGANZ (III)  Room 309, Steele Building, School of Pharmacy

09:00 – 10:30

Prof Mats Karlsson, Department of Pharmacy, University of Uppsala, Sweden

Estimation of Optimal Dose Individualization Strategies

Dr Diane Mould, SmithKlineBeecham, Pennsylvania, USA

A Population Pharmacokinetic and Pharmacodynamic Analysis of Drug “X”


10:30 – 11:00

Morning tea


11:00 – 13:00

Assoc Prof Nick Holford, Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, NZ

Overview of the WinNONMIX program

Dr Noel Cranswick, Clinical Pharmacology, Royal Children’s Hospital, Melbourne

Using WinNONMIX to Model Paediatric Pharmacokinetic Data – A Layperson’s Approach

Dr Diane Mould, SmithKlineBeecham, Pennsylvania, USA

Assessing Pharmacokinetic and Pharmacodynamic Drug Interactions with Drug “X”


13:00 – 14:00

Lunch (UQ Staff Club)


14:00 – 15:30

Assoc Prof Nick Holford, Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, NZ

Three Stage Model Evaluation – A Form of Posterior Predictive Check

Mr John Parke, Chief Pharmacist, QEII Hospital, Brisbane

Role of the Bootstrap Approach in Evaluating Population Models



General discussion, closing remarks

Afternoon tea, farewells




There is a large variety of accommodation in Brisbane City or in the immediate surrounds, including many modern hotels of international standard (e.g. Hilton, Sheraton, Marriott). Those listed below are included only to indicate the range available. Delegates should make their own arrangements for travel, transfers and accommodation. The rates and conditions quoted below should be confirmed with the hotel beforehand. To qualify for any university/hospital/government rate delegates should bring a business card, employee declaration, pay advice, etc.


Rydges Brisbane Southbank

Glenelg Street

South Brisbane QLD 4101

+61 7 3255 0822 (Tel)

+61 7 3255 0899 (Fax)

[email protected]

A new, high quality hotel located in the Southbank area, and adjacent to the Performing Arts complex, museums, eateries. A pleasant 10 min walk across Victoria Bridge into the City. Special university conference rate:  $120 – $140 double/twin


The Heritage Hotel

39 Edward Street

Brisbane, QLD 4000

+61 7 3221 1999 (Tel)

+61 7 3221 6895 (Fax)

[email protected]

This is one of the best hotels in Brisbane situated in the City on the Brisbane River adjacent to the Botanic Gardens. Where the celebrities stay when in town! Special rate for universities, government departments, hospitals:  $165 double/twin

Normal rate:  $230 double/twin

Qantas Frequent Flyer rate:  $200 double/twin



Inn on the Park

507 Coronation Drive

Toowong, QLD 4066

+61 7 3870 9222 (Tel)

+61 7 3870 2246 (Fax)

[email protected]

A smaller establishment with a unique colonial appeal on the Brisbane River halfway between the City and the University of Queensland (approx 4 km away).

$95 single/twin/double (>2 nights stay attracts a welcome dinner to the value of $30).


Coronation Motel

205 Coronation Drive

Milton QLD 4064

+61 7 3369 9955 (Tel)

+61 7 3369 5066 (Fax)

[email protected]

Situated on the main route between the City and University of Queensland.

$79 single/double/twin


The Women’s College

College Road

The University of Queensland, QLD 4072

+61 7 3377 4500 (Tel)

+61 7 3870 9511 (Fax)

[email protected]

A major residential college located on campus a few minute’s walk from the centre of the University via the river, lakes and parklands. It offers single rooms with shared facilities at $50 per night, including cooked breakfast.





PAWS  + PAGANZ                $175

PAGANZ                                $100


Registration deadline is Monday, January 24, 2000.

The registration fee covers attendance, morning and afternoon refreshments (coffee/tea/juice/mineral water), lunches and honorary membership at the University of Queensland Staff Club (31st January – 2nd February, inclusive), conference dinner  including CityCat (high-speed catamaran) transport down river from the University of Queensland to Southbank. Cost of an accompanying person for the dinner is $40.


Payment should be in Australian dollars by cheque, or by an international bank draft drawn on an Australian bank (e.g. Commonwealth Bank) for overseas delegates. Make all cheques payable to: THE UNIVERSITY of QUEENSLAND

A receipt of payment will be issued at the meeting.


As advised previously, the number of computer workstations available for the PAWS section of the meeting is limited, therefore, places will be allocated on a first-come basis. Registration will be confirmed only on receipt of payment (Sorry, we cannot handle credit card transactions or EFT for this meeting).

There is no restriction on numbers for the PAGANZ section of the meeting.


To register for PAWS-PAGANZ 2000 complete the Attached registration form and mail with payment to:


BG Charles


School of Pharmacy

The University of Queensland

QLD 4072  Australia




You are encouraged to present planned, in-progress, or completed population studies (15:30-17:30, Tuesday, February 1st) in an informal environment. These will be of 10-15 minutes duration with 5-10 minutes for discussion/questions depending on the final number of submissions. There will be computer presentation facilities, 35 mm slide projector, overhead projector, and whiteboards available. Those intending to present should submit an abstract of no more than 1 page, with title, authors(s) and institution(s) and send this to me as an email Attachment.




The meeting is being held at The University of Queensland, Brisbane, St Lucia campus. The PAGANZ section will be held in the School of Pharmacy, Room 309, Steele Building (building No. 3 on the University map which is displayed throughout the campus). Attendees should report here by 08:30 on Monday, January 31. The PAWS sessions will be conducted in the PC laboratory on the ground floor of the Biological Sciences Library (building No. 94). Lunches and drinks will be in the Staff & Graduates Club, Staff House (building No. 41).




All queries for PAWS-PAGANZ 2000 should be directed to:



University of Queensland, School of Pharmacy, QLD 4072


+61 7 336 53194 (TEL)

+61 7 336 51688 (FAX)

[email protected]