Background: There is increasing evidence in recent years of the therapeutic benefits of induced mild ketosis in various neurological disorders. A novel means of achieving ketosis is by nutritional consumption of a ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate) that hydrolyses to D-β-hydroxybutyrate (BHB).[1] The absorption of ketone monoester and BHB and its disposition appears to be complicated.[2] […]
Author: Vittal Shivva
Population pharmacokinetic model for D-β-Hydroxybutyrate following ketone monoester ingestion
Background: Ketone bodies, the evolutionary response to starvation in humans, are produced in the liver from fatty acids in response to low blood glucose and insulin, and used by the body as fuels. Ketogenic diets have long been used to treat intractable paediatric epilepsy, with therapeutic evidence for ketosis in other neurodegenerative disorders such as […]
Identifiability of Population Pharmacokinetic-Pharmacodynamic Models
Background: Mathematical models are routinely used in clinical pharmacology to study the time course of concentration and effect of a drug in the body. Identifiability of these models is an essential prerequisite for the success of these studies.1 Identifiability is classified into two types, structural identifiability related to the structure of the mathematical model and […]