Model-based estimation of anticholinergic burden

Background: Older people exposed to medicines with anticholinergic properties are at an increased risk of experiencing adverse events. Anticholinergic burden refers to exposure to 1 or more medicines with anticholinergic activity. Studies have reported anticholinergic burden to be a strong predictor of cognitive and physical impairment in older people1. Background work in this area has […]

Estimating the relative potencies of an anticholinergic medicine: A methodological view point

Background Older people continue to be prescribed medicines with anticholinergic properties and are at an increased risk of experiencing adverse events with these medicines.1 Exposure to 1 or more medicines with anticholinergic properties is termed anticholinergic burden.2 Tools to quantify anticholinergic burden have been developed, but the major drawbacks of these tools are the limited […]