Background. Numerous population pharmacokinetic (popPK) models of tacrolimus (TAC) in adult transplant recipients have been published. However, data on the accuracy of Bayesian forecasting with concomitant azole therapy or extrapolation to other transplant cohorts are scarce. Aims. To externally validate the predictive performances of relevant popPK models of TAC in adult heart transplant (HTX) recipients […]
Archive | Abstracts
Quantifying the Dose-Response of Unfractionated Heparin Using a System Pharmacology Model of Coagulation
January 15, 2019
Authors Abdallah Derbalah (1), Stephen Duffull (1), Hesham Al-Sallami (1)
Affiliations University of Otago
Presentation type Oral
Presenters Abdallah Derbalah
Introduction: Unfractionated heparin (UFH) is commonly used in the treatment and prevention of a variety of thromboembolic disorders. Its short duration of action and reversibility of its effect with the use of protamine sulphate make it the agent of choice in acute settings such as cardiac surgery. However, optimal dosing of UFH remains challenging partly due […]
A Population Pharmacokinetic Model of Phenobarbitone in Neonates to Determine Oral Bioavailability and Facilitate Individualised Dosing
January 15, 2019
Authors Angela Williams (1), Tim Donovan (2), Bruce Charles (1), Christine E. Staatz (1).
Affiliations 1. The University of Queensland, School of Pharmacy, Brisbane, QLD, Australia. 2. The Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia
Presentation type Oral
Presenters Angela Williams
Background: Phenobarbitone is the most commonly used first-line drug for the treatment of neonatal seizures. A number of previous studies, with small subject numbers, have identified covariates that may influence the pharmacokinetics of phenobarbitone but results have been inconsistent. In particular, oral bioavailability is relatively poorly described and doses are commonly reported as being the […]
PBPK modeling for lindane across different species
January 15, 2019
Authors Shengjie Zhang, Harvey Ho
Affiliations University of Auckland
Presentation type Poster
Presenters Shengjie Zhang
Interspecies differences are one of the important factors to consider when extrapolating a physiologically based pharmacokinetic (PBPK) model from one species to another. As some of the parameters used in PBPK models are not always available from in-vitro/in-vivo experiments or previous literature, it is important to know how to estimate the parameters from one species […]
Modelling of delivery kinetics of gentamicin administered through umbilical long lines
January 15, 2019
Authors Gianna Salis (1), Natalie Medlicott (2), David Reith (1).
Affiliations 1. Women's and Children's Health, Dunedin School of Medicine, University of Otago, 2. New Zealand's National School of Pharmacy, University of Otago
Presentation type Oral
Presenters Gianna Salis
Introduction:Gentamicin is commonly used in the NICU setting and is often administered via long lines, such as umbilical venous catheters, which increases variability in the rate of administration. This variability is not taken into account when considering drug delivery in neonates and recommendations are extrapolated from adult data. We aimed to model drug delivery parameters […]
A Population Pharmacokinetic Study of Caffeine Citrate in Chinese Premature Neonates
January 15, 2019
Authors Xiaoyan YANG (1，2)，Nick HOLFORD (2)，Zhimei JIANG (3)，Hongxin SHEN (3)，Jing SHI (1)*，Xianxiao SHU (1)，Yi HUANG (1)，Jing ZHAO (1)，Jun TANG (1)，Dezhi MU (1)
Affiliations 1. Department of Pediatrics, West China Second University Hospital, Sichuan University Chengdu 610041, China; 2. Dept Pharmacology & Clinical Pharmacology, University of Auckland, Auckland 1010, New Zealand; 3. Department of Pharmacology, West China Second University Hospital, Sichuan University Chengdu 610041, China
Presentation type Oral
Presenters Xiaoyan YANG，Nick HOLFORD
Objective: Apnea of prematurity (AOP) is defined as an attack of apnea for at least 20 seconds, with bradycardia and cyanosis. It is a common phenomenon in the neonatal intensive care unit (NICU). Caffeine citrate, one of the methylxanthines, is used to suppress or to prevent AOP attack. This study aimed to develop a population pharmacokinetic (popPK) […]
Future work in Auckland: procalcitonin in healthy and infected neonates to inform PKPD disease progression modelling
January 15, 2019
Authors Jacqueline Hannam (1), Nicholas G. Holford (1), Brian J Anderson (2, 3)
Affiliations 1. Department of Pharmacology & Clinical Pharmacology, The University of Auckland, Auckland, New Zealand. 2. 1. Department of Anaesthesiology, The University of Auckland, Auckland, New Zealand. (3) Starship Children’s Hospital, Auckland District Health Board, Auckland, New Zealand.
Presentation type Oral
Presenters Jacqueline Hannam
Appropriate antimicrobial therapy in neonates and babies is complicated by pharmacokinetic (PK) changes with age, body size and disease. Additionally we lack pharmacodynamic (PD) measures to gauge patient response. A correlation exists between elevated concentrations of procalcitonin (PCT) and infection +/- sepsis butmultiple other factors also contribute to PCT fluctuations (1, 2). For example, PCT […]
Parameter Analysis for PBPK Model for Enalapril
January 15, 2019
Authors Zhe Yang (1), Dr David Nickerson (2), Prof Peter Hunter (3), Dr Harvey Ho (4)
Affiliations University of Auckland
Presentation type Poster
Presenters Zhe Yang
Physiologically based pharmacokinetic (PBPK) modeling is valuable for drug development (Phase I). While PBPK models may share similar compartmental structures (e.g., blood, liver) for different species, a distinct set of physiological (e.g. compartmental volume and blood flow rate) and drug-specific (e.g. metabolism and clearance rates) parameters need to be used in different species. However, it […]
Simulations to explore studies of propofol infusions in neonates and infants
January 15, 2019
Authors James D Morse (1), Jacqueline A Hannam (1), Brian J Anderson (2, 3)
Affiliations 1 Department of Pharmacology & Clinical Pharmacology, University of Auckland, New Zealand 2 Department of Anaesthesiology, University of Auckland, New Zealand 3 Department of Anaesthesia, Starship Children’s Hospital, Auckland, New Zealand
Presentation type Oral
Presenters James D Morse
There are no validated propofol infusion regimens in neonates and infants. Existing pharmacokinetic pharmacodynamic (PKPD) models do not include data from babies under the age of 1 year (1) making dosing in this population empirical, largely based on recommendations from Steur et al (2). Steur and colleagues recommend a bolus dose between 3-5 mg·kg-1 followed by infusion rates […]
PAGANZ Workshop: CellML and OpenCOR
January 15, 2019
Authors Soroush Safaei (1), Steve Duffull (2)
Affiliations (1) Auckland Bioengineering Institute, University of Auckland (2) Otago Pharmacometrics Group, School of Pharmacy University of Otago
Presentation type Oral
Presenters Soroush Safaei
Over the past 10 year quantitative systems pharmacology has become an integral part of pharmacometrics. While the models and methods used in a QSP framework are novel to pharmacometricians they have been well established in the disciplines of systems biology and bioengineering. Software (e.g. CellML, SBML, …) for specifying models and enabling simulations from models […]