Objectives: Our longitudinal frailty modelling in ageing mice (12 to 27 months) was affected by substantial late-stage data censoring due to scheduled tissue collection or intervention related dropout, particularly at the 24- and 27-month time points. During longitudinal frailty model building, a likelihood based M3 method was combined with a cut-off threshold based on the […]
2026
Alternative Approaches in Evaluating the Pharmacokinetics of Ceftazidime-Avibactam in Paediatrics and Adults
Anti-infective drug development requires model-informed approaches to optimise dosing across ages. While paediatric pharmacokinetic studies often extrapolate from adult population pharmacokinetic (PopPK) models, physiological differences and variations in data richness can limit direct extrapolation. Ceftazidime-avibactam, an antibacterial combination licensed across all ages, provides a strong test case for developing robust extrapolation methods. This study therefore […]
Physiologically Based Pharmacokinetic Modelling of Enantiomeric Tramadol and Its Active Metabolite Across CYP2D6 Phenotypes
Tramadol (TM) is a centrally acting opioid analgesic, commonly implicated in drug overdose, driving under the influence or drug facilitated sexual assault investigations (Fernando et al 2026). Interpretation of tramadol concentrations in clinical and forensic toxicology poses a number of challenges owing to the impact of inter-individual variation in drug disposition and response, much of […]
Modelling of red blood cell turnover to determine safe dosing strategies for treatment of vivax malaria patients
Introduction: Primaquine is the only widely available drug that targets Plasmodium vivax malaria parasites in the liver. However, primaquine is underused because of concerns that this drug can cause dose-dependent haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. We developed and calibrated a within-host Bayesian pharmacodynamic model of red blood cell (RBC) production and turnover to […]
Population Pharmacokinetic Modeling of Tacrolimus with CYP3A5 Genotype Integration in Vietnamese Liver Transplantation: Toward Precision Dosing
Introduction: Tacrolimus (TAC) is a cornerstone immunosuppressant in liver transplantation, characterized by a narrow therapeutic index and substantial pharmacokinetic variability, making dose optimization challenging. Objective: This study aimed to develop a population pharmacokinetic (PopPK) model for TAC in Vietnamese liver transplant patients, integrating CYP3A5 genetic polymorphisms to support individualized dosing. Methods: Data from 95 Vietnamese liver […]
In Vitro Anticancer and Cell Migration Inhibitory Activities of Novel Quinoline Derivatives Against MCF-7 Breast Cancer Cells
Background: Breast cancer remains a leading cause of cancer-related mortality worldwide, with therapeutic outcomes frequently limited by drug resistance, toxicity, and metastatic progression. Quinoline-based heterocycles have emerged as promising anticancer scaffolds owing to their diverse pharmacological properties and amenability to structural modification. This study evaluated the antiproliferative and cell migration inhibitory activities of a novel […]
From Pills to Pathways: Geriatric Pharmacology Through the Lens of Proteomics and Systems Pharmacology
Older people are major users of medicines. In addition to highly prevalent use of multiple medications (polypharmacy), ageing is accompanied by multisystem physiological decline over time with major implications in pharmacodynamics and pharmacokinetics. Accumulating clinical evidence demonstrates that certain commonly prescribed drugs and polypharmacy are associated with adverse geriatric outcomes, such as falls, frailty and […]
Ivermectin therapy for young children less than 2 years with scabies infection: a multicentre phase 2 non-randomised trial
Background: Ivermectin is effective for treating scabies but is unlicensed for children <15 kg. Our previous trial in children aged 2-4 years showed ivermectin was safe and effective, with a 3 mg dose achieving drug exposures comparable to the licensed dose in children weighing ≥15 kg. Using population pharmacokinetic modelling, an age-based dosing strategy for […]
Framework for developing a Health Decision Support System
Decision Support Systems (DSS) represent a concept of the role of computers within the decision-making process. In this work we propose a framework that will assist decision makers. The conceptual model of the system showing various modules and entities that constitute the proposed system is presented. In this paper, we are concerned with rational decision-making […]
Model-Integrated Evidence for Delafloxacin: Minimal PBPK-PD Simulations and Network Meta-Analysis to Support Urinary Tract Infection Indication Development
Introduction: Delafloxacin is a novel anionic fluoroquinolone with broad-spectrum activity against aerobic and anaerobic Gram-positive and Gram-negative pathogens, including several clinically relevant resistant organisms. Although delafloxacin has primarily been developed and approved for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, its antibacterial spectrum, dual intravenous and oral formulations, and renal elimination […]