Evaluating the robustness of the M3 Method for Handling Late-Stage Data Censoring in Longitudinal Mouse Frailty Models: A Simulation-Estimation Study

Objectives: Our longitudinal frailty modelling in ageing mice (12 to 27 months) was affected by substantial late-stage data censoring due to scheduled tissue collection or intervention related dropout, particularly at the 24- and 27-month time points. During longitudinal frailty model building, a likelihood based M3 method was combined with a cut-off threshold based on the […]