uster

Abstracts

Improved predictive performance using a model averaging algorithm in model-informed precision dosing of vancomycin

David W. Uster (1), Sophie L. Stocker (2,3), Jane E. Carland (2,3), Richard O. Day (2,3,4), Sebastian G. Wicha (1)
(1) Dept. of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Hamburg, Germany (2) Dept. of Clinical Pharmacology & Toxicology, St Vincent’s Hospital, Sydney, Australia (3) St Vincent's Clinical School, University of New South Wales, Sydney, Australia (4) School of Medical Sciences, University of New South Wales, Sydney, Australia
January 10, 2021February 2, 2021

Background: Currently, the recommendation for therapeutic drug monitoring (TDM) of vancomycin is shifting towards AUC-guided dosing through model-based precision dosing (MIPD). However, selecting the correct model is crucial to give appropriate dose recommendations (Broeker et al. CMI, 2019). The aim of the present study was to derive and evaluate a model averaging algorithm (MAA), which […]