Navigation

David McDougall

  • University of Queensland

Author Archive | David McDougall

Assessing the predictive performance of an interactive application to dose adjust voriconazole

January 22, 2017

Authors David McDougall (1,2) & Bruce Green (1)
Affiliations 1. Model Answers Pty Ltd, Brisbane, Australia; 2. School of Pharmacy, University of Queensland, Brisbane, Australia
Presentation type Oral
Presenters David McDougall

Attachments
Figure 1

Aims Voriconazole is a broad spectrum triazole antifungal used as first line therapy for invasive infections. Pharmacokinetic (PK) studies have indicated large between subject variability between dose and exposure, which has prompted the use of therapeutic drug monitoring (TDM) to optimise dosing [1].  Voriconazole also exhibits large within subject variability, potentially limiting the utility of […]

Continue Reading

Development of an Interactive Tool to Explore Doses & Sample for Paediatric Trials

January 22, 2017

Authors Michael Cheng (1), David McDougall (1), Bruce Green (1)
Affiliations 1. Model Answers Pty Ltd
Presentation type Poster
Presenters David McDougall

Attachments
Figure 1

Aims: The aim of this work was to develop an interactive tool that allows users to (1) explore paediatric dose levels that provide a similar exposure as predicted for an adult reference population, and (2) calculate the sample size required for a pharmacokinetic (PK) study in paediatrics based on FDA guidance [1,2]. Methods: A virtual […]

Continue Reading