Assessing the predictive performance of an interactive application to dose adjust voriconazole

Aims Voriconazole is a broad spectrum triazole antifungal used as first line therapy for invasive infections. Pharmacokinetic (PK) studies have indicated large between subject variability between dose and exposure, which has prompted the use of therapeutic drug monitoring (TDM) to optimise dosing [1].  Voriconazole also exhibits large within subject variability, potentially limiting the utility of […]

Development of an Interactive Tool to Explore Doses & Sample for Paediatric Trials

Aims: The aim of this work was to develop an interactive tool that allows users to (1) explore paediatric dose levels that provide a similar exposure as predicted for an adult reference population, and (2) calculate the sample size required for a pharmacokinetic (PK) study in paediatrics based on FDA guidance [1,2]. Methods: A virtual […]