Preliminary development of a semi physiologically-based pharmacokinetic model for rocuronium

Introduction: Rocuronium is commonly used to temporarily paralyse the muscles of the jaw and voice box to facilitate intubation. In the first few minutes after rapid IV administration, cardiac output (CO) is a primary determinant of arterial blood concentrations, and thus effect, for many drugs.  In particular, CO can be significantly altered in emergency patients. […]