Background: A previously developed semi-mechanistic model [1] linked fasting serum insulin (FSI), fasting plasma glucose (FPG), and glycosylated haemoglobin (HbA1c) to characterise the disease progression of newly diagnosed type 2 diabetic (T2DM) patients. To build upon the model, weight change (DWT) as an effector to the FSI-FPG-HbA1c relationship was implemented in the present study. Methods: […]
Nick Holford Prize
A reduction in between subject variability is not mandatory when adding a new covariate
Background: Population pharmacokinetic-pharmacodynamic (PKPD) analysis involves nonlinear hierarchical modelling where the mean response in a population and the variability in response from different sources are studied. It consists of two model hierarchies: a model for residual error and a model for heterogeneity termed between subject variance (BSV). The overall variability in a parameter within a […]
Identification and initial evaluation of a prototype clotting time test for enoxaparin
Background: Enoxaparin is a low molecular weight heparin anticoagulant and is widely used in thromboprophylaxis for both prevention of primary thrombosis and at higher doses for treatment in patients with pulmonary embolism, deep vein thrombosis and acute coronary syndromes. Dosing of enoxaparin, like other anticoagulants, may result in bleeding following excessive doses and clot formation if […]