Background. Therapeutic drug monitoring (TDM) for levofloxacin, a key multi-drug-resistant tuberculosis (MDR-TB) drug, is highly recommended but widely impractical. Saliva sampling with limited sampling strategy offers a non-invasive and more feasible alternative to blood for TDM, yet no validated saliva model exists to guide dosing. Aim. To develop a saliva population pharmacokinetic (PK) model for […]
Author: Thi
Saliva Population Pharmacokinetic Modelling and Simulation of Linezolid in Multi-Drug Resistant Tuberculosis
Background. Therapeutic drug monitoring (TDM) for linezolid, an essential MDR-TB drug, is strongly recommended but often impractical. Saliva sampling with limited sampling strategy presents a non-invasive and more feasible alternative to blood, but a validated saliva model for dosing guidance is lacking. Aim. To develop a saliva population pharmacokinetic (PK) model for linezolid in Vietnamese […]
Analytical and non-analytical variation may lead to inappropriate antimicrobial dosing in neonates: an in silico study
Background. Therapeutic drug monitoring (TDM) of aminoglycosides and vancomycin is used to prevent oto- and nephrotoxicity in neonates. Analytical and non-analytical factors potentially influence dosing recommendations. Aim. To determine the impact of analytical variation (imprecision and bias) and non-analytical factors (accuracy of drug administration time, use of non-trough concentrations, biological variation and dosing errors) on […]