Population Pharmacokinetics of Piperacillin-Tazobactam in Children’s Plasma and Cerebrospinal Fluid Across a Wide Spectrum of Childhood Ages

Introduction: Piperacillin-tazobactam is a combined β-lactam and β-lactamase inhibitor with broad spectrum and time-dependent antibacterial activity commonly prescribed in children. Despite there were several paediatric population pharmacokinetic (PPK) studies, PPK studies on cerebrospinal fluid (CSF) are still in absence. As a time-dependent β-lactam antibacterial agent, if prolonged infusions improve the target attainments also need further […]

Serum ganciclovir drug exposure in children receiving standard ganciclovir and valganciclovir dosing

Introduction: Intravenous ganciclovir (IV GCV) or its oral prodrug, valganciclovir (VGCV), is used for the prevention and treatment of cytomegalovirus (CMV) infection in immunocompromised children. Studies shown a serum area under the concentration-time curve (AUC24) of ≥ 40mg·h/L is required for effective CMV prevention. Aims: To determine a population pharmacokinetic model for immunocompromised children, evaluate […]