Hepatic Protein Signatures of Chronic Polypharmacy, Monotherapy, and Deprescribing in Aged Mice

Introduction. Polypharmacy is common in old age and is associated with adverse geriatric outcomes. Deprescribing medications may alleviate some outcomes. The liver is a key metabolic organ and is affected by drugs and ageing. However, the molecular effects of chronic monotherapy, polypharmacy, and deprescribing in the ageing liver remains uncharacterised. Aims. In aged mice, to […]