Population Pharmacokinetic Parent-Metabolite Modeling of Tenofovir Alafenamide in Healthy Korean Volunteers

Background: Tenofovir alafenamide (TAF) is widely used drug as a first-line drug for managing hepatitis B virus infection. TAF was developed as the prodrug of tenofovir (TFV) to decrease renal and bone toxicities through lower dose administration and sufficient systemic exposures than other salt forms of TFV. TAF is also a highly variable drug in […]