Background: Vancomycin dosing is commonly adjusted using therapeutic drug monitoring (TDM), traditionally guided by trough concentrations. An Auckland before-after cohort study evaluated a local change from empirical trough-guided TDM to NextDose-informed Bayesian 24-hour area under the concentration-time curve (AUC24)-guided target concentration intervention (TCI). In routine care, dosing performance is shaped by pharmacokinetics and ward execution, […]
