Modeling of blood pressure lowering effect for co-administration of valsartan and amlodipine

Background: The objective of this study was to develop a pharmacodynamic (PD) model for antihypertensive effect of amlodipine and valsartan combined therapy. Methods: Pharmacokinetic (PK) modeling was first carried out for both drugs using data collected from 48 healthy volunteers receiving a combined formulation of 10mg amlodipine and 160mg valsartan as a single dose. Systolic […]