Introduction: Pharmacometrics time-to-event (TTE) modelling complements therapeutic drug monitoring (TDM) in assessing drug efficacy and safety. In atrial fibrillation (AF) patients on rivaroxaban, heart failure (HF) is an independent predictor of bleeding. Given rivaroxaban’s high protein binding and hepatic metabolism, organ congestion in HF may influence drug disposition and anticoagulation outcomes. Objectives: This study aimed […]
