Modelling analgesia-concentration relationships for morphine in an experimental pain setting

Aims: To develop a population pharmacokinetic-pharmacodynamic (PK-PD) model describing the concentration-effect relationships for morphine on experimental pain caused by skin heat and muscle pressure. Methods: Data were analysed from a study of 39 healthy volunteers who received 30 mg oral morphine, or placebo. Blood samples were collected up to 150 min post-dose, while experimental skin […]