February 4, 2013
Authors Eva Sverrisdóttir (1), Richard Upton (2), Mads Kreilgaard (1), Anne Estrup Olesen (3), David Foster (2)
Affiliations (1) Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, (2) Australian Centre for Pharmacometrics, School of Pharm and Med Sci, UniSA, Adelaide, SA, (3) Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Denmark
Presentation type Oral
Presenters Eva Sverrisdóttir
Aims: To develop a population pharmacokinetic-pharmacodynamic (PK-PD) model describing the concentration-effect relationships for morphine on experimental pain caused by skin heat and muscle pressure. Methods: Data were analysed from a study of 39 healthy volunteers who received 30 mg oral morphine, or placebo. Blood samples were collected up to 150 min post-dose, while experimental skin […]
