Population pharmacokinetic modelling of fentanyl for pain management in cancer patients

Background: Pain is a frequent complication of advanced cancer. Opioids are used to control severe pain. Unfortunately, they have a number of side-effects with little difference between the dose that will control pain and that which will cause toxicity. A range of factors such as age/sex/dose/delivery system/genetic variations/kidney and liver function influence how opioids are […]