In silico modelling for transplacental transfer of morphine in an ex vivo human cotyledon perfusion system

Transplacental properties of drugs are important for the well-being of fetuses. However, in vivo data on the transplacental effects of most drugs are rare due to ethical issues and technical challenges. Hence, ex vivo placenta cotyledon perfusion experiments have been used to investigate the transplacental properties since the 1960s. Recently there have been some efforts […]

Pharmacokinetic modelling for remdesivir

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has resulted in a global pandemic that demands urgent abatement solutions. Remdesivir (RDV) has been used as a compassionate-use-drug for managing COVID-19 patients and approved by FDA, yet the clinical performances of RDV were controversial. In addition, pharmacokinetic data have not sufficiently collected from different age groups […]

PBPK modeling for lindane across different species

Interspecies differences are one of the important factors to consider when extrapolating a physiologically based pharmacokinetic (PBPK) model from one species to another. As some of the parameters used in PBPK models are not always available from in-vitro/in-vivo experiments or previous literature, it is important to know how to estimate the parameters from one species […]