Author Archive | SherryZ

Pharmacokinetic modelling for remdesivir

The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has resulted in a global pandemic that demands urgent abatement solutions. Remdesivir (RDV) has been used as a compassionate-use-drug for managing COVID-19 patients and approved by FDA, yet the clinical performances of RDV were controversial. In addition, pharmacokinetic data have not sufficiently collected from different age groups […]

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PBPK modeling for lindane across different species

Interspecies differences are one of the important factors to consider when extrapolating a physiologically based pharmacokinetic (PBPK) model from one species to another. As some of the parameters used in PBPK models are not always available from in-vitro/in-vivo experiments or previous literature, it is important to know how to estimate the parameters from one species […]

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