shase914

  • University ofOtago

Author Archive | shase914

Exploring and optimising the computational efficiency of Inductive Linearisation for estimation

Background: Determining the optimal choice of a dose of medicine to meet the patient’s need is a complicated mathematical and statistical problem. Large between-subject variability in metabolic, excretion processes, and physiological systems involving drug effect, as well as complicated nonlinearities, are at the heart of the problem. This leads to nonlinear differential equations that need […]

Continue Reading