shanmdphd

Abstracts

Pharmacokinetics and Pharmacodynamics of TU2670 (nonpeptide GnRH antagonist) in healthy female subjects

Soo Hyeon Bae (1), Sunmi Kim (2), Sangil Jeon (1), Kyunseop Bae (3), Seunghoon Han (4,5), Dong-Seok Yim (4,5), Sungpil Han (4,5)
1. Q-fitter, Inc., 2. TiumBio, Inc., 3. Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, 4. Department of Pharmacology, College of Medicine, the Catholic University of Korea, 5. PIPET (Pharmacometrics Institute for Practical Education and Training), College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea
January 16, 2023April 8, 2025

OBJECTIVE: TU2670 is a novel competitive pituitary GnRH receptor antagonist to treat endometriosis. We investigated the safety, tolerability, pharmacokinetics and pharmacodynamics of TU2670 after multiple oral administration in healthy female subjects. Population PK/PD analysis using pooled phase I clinical trial data was also performed to suggest efficacious doses to treat endometriosis. DESIGN: Phase I, single-blind, […]