Background A common method of measuring the predictive performance of models was described by Sheiner and Beal in 1981. They suggested measuring predictive performance by expressing bias and imprecision of the model by calculating the mean prediction error (MPE) and the root mean squared error (RMSE). There are occasions where the 95% confidence interval of […]
Author: Shamin Saffian
The influence of CYP2C9 and VKORC1 genotype on the predictive performance of a Bayesian forecasting method for warfarin therapy
Introduction. Genetic differences in warfarin metabolism (via CYP2C9) and vitamin K recycling (VKORC1) have been found to significantly influence warfarin maintenance dose requirements. A Bayesian forecasting method for warfarin therapy should predict dosing requirements without prior genetic data. Aims. The aim of this study was to determine the influence of CYP2C9 and VKORC1 genotype on […]