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Shamin Saffian

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A suggestion for determining systematic bias when measuring predictive performance

January 25, 2015

Authors Shamin Saffian, Dan Wright, Stephen Duffull
Affiliations University of Otago, Dunedin, New Zealand
Presentation type Oral
Presenters Shamin Saffian

Background A common method of measuring the predictive performance of models was described by Sheiner and Beal in 1981. They suggested measuring predictive performance by expressing bias and imprecision of the model by calculating the mean prediction error (MPE) and the root mean squared error (RMSE). There are occasions where the 95% confidence interval of […]

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The influence of CYP2C9 and VKORC1 genotype on the predictive performance of a Bayesian forecasting method for warfarin therapy

January 24, 2014

Authors Shamin M Saffian(1), Daniel F B Wright (1), Rebecca L Roberts(2), Robert C. Tait (3), Leanne Black (4), Kirsten Lund (3) Stephen B Duffull(1)
Affiliations 1. School of Pharmacy, University of Otago, Dunedin, 2. Department of Surgical Services, University of Otago, Dunedin, 3. Department of Haematology, Royal Infirmary, Glasgow, 4. Pharmacy Department, Royal Infirmary, Glasgow
Presentation type Oral
Presenters Shamin M Saffian

Introduction. Genetic differences in warfarin metabolism (via CYP2C9) and vitamin K recycling (VKORC1) have been found to significantly influence warfarin maintenance dose requirements. A Bayesian forecasting method for warfarin therapy should predict dosing requirements without prior genetic data. Aims. The aim of this study was to determine the influence of CYP2C9 and VKORC1 genotype on […]

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