Application of Item Response Theory to ADAS-cog Scores Modelling in Alzheimer’s Disease

Background: The challenges in the development of new therapeutic agents for Alzheimer’s Disease (AD) become apparent through the high number of failed late phase trials. Despite an increasing interest in biomarkers, cognition remains the primary regulatory accepted clinical outcome. The most frequently used test, ADAS-cog, consists of a broad spectrum of tasks that test different […]