Our overarching aim has been to bring better dosing methods to the ward, meaning we aim not only to make pharmacometric model-based calculations useable by clinicians, but to actually get them to use it. We want doses to be determined by the best possible method, meaning real patients receiving doses that were determined (at least […]
Sam Holford
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- Te Whatu Ora Counties Manukau
Author Archive | Sam Holford
Antibiotic Dosing Calculator in Neonates and Children Trial
January 29, 2011
Authors Sam Holford (1), Carissa Herbert (1), Brian J. Anderson (2), Nick Holford (3)
Affiliations (1) School of Medicine, (2) Department of Anaesthesiology, (3) Department of Pharmacology and Clinical Pharmacology; University of Auckland, Auckland, New Zealand
Presentation type Poster
Presenters Sam Holford
Research question: Does the dosing regimen (dose and dose interval) proposed by the dose calculator result in serum concentrations closer to the target concentration than the dose regimen achieved by currently used protocols? Background: A dosing calculator has been developed based on a pharmacokinetic analysis of vancomycin (532 subjects, 1676 concentrations), amikacin (682 subjects, 1717 […]
What is needed for a dosing calculator?
January 28, 2011
Authors Brian Anderson (1), Carissa Herbert (2), Nick Holford (3), Sam Holford (4)
Affiliations (1) Department of Anaesthesiology, (2) School of Medicine, (3) Department of Pharmacology and Clinical Pharmacology; University of Auckland, Auckland, New Zealand
Presentation type Oral
Presenters Sam Holford
Background: Once daily dosing of aminoglycosides is popular because these drugs have a concentration-dependent bactericidal spectrum and nephrotoxicity is related to a saturable uptake by the proximal renal tubules. High peak concentrations and low trough concentrations are consequently desirable. Current dosing of both aminoglycosides and glycopeptides for children in intensive care is protocol driven. Dosing in […]
Online dose calculation tool for determining dosing regimens in the very young
January 3, 2010
Authors Sam Holford (1), Nicholas H.G. Holford (1), Brian J. Anderson (2)
Affiliations (1) Department of Pharmacology and Clinical Pharmacology, (2) Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
Presentation type Poster
Presenters Sam Holford
Few tools are available to quickly calculate dose in neonates. A dosing calculator has been developed using age, weight and renal function. The aim of this calculator is to provide quick and accurate predictions of average steady state concentration (Csspred) and expected time course for a range of dosing regimens in neonates. The dosing calculator […]
Pharmacokinetics of Tramadol in Human Neonates, Children and Adults and in Adult Rats, Cats, Dogs, Goats and Horses
January 26, 2009
Authors Sam Holford (1), Karel Allegaert (2), Brian J. Anderson (3), Nick H.G. Holford (1)
Affiliations (1) Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand , (2) Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium , (3) Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
Presentation type Oral
Presenters Sam Holford
Objective: To describe human maturation and between species differences in tramadol disposition. Background: (+)-Tramadol (tramadol) and its phase I metabolite (+)-O-desmethyltramadol (M1) are weak µ-opioid receptor agonists that are structurally related to morphine. The O-demethylation of tramadol to M1, the main analgesic metabolite, is catalysed by CYP2D6. CYP2D6 polymorphisms have been shown to influence M1 production and […]