Introduction. External evaluation of published tacrolimus population pharmacokinetic models (n=17) highlighted that no available model accurately describes tacrolimus disposition in heart transplant (HTX) recipients, both with and without concomitant azole antifungal therapy.1 Concomitant azole antifungal therapy alters tacrolimus disposition substantially necessitating dose adjustments. The incorporation of azole antifungal use as a covariate may improve model-predicted […]
Ranita Kirubakaran
Author Archive | Ranita Kirubakaran
External evaluation of population pharmacokinetic models of tacrolimus in adult heart transplant recipients
December 5, 2019
Authors Ranita Kirubakaran (1,2), Stefanie Hennig (3,4), Ben Maslen (5), Jane E Carland (1,2), Richard O Day (1,2), Sophie L Stocker (1,2)
Affiliations 1. St Vincent's Clinical School, UNSW, Sydney, 2. Dept of Clin Pharmacol and Toxicol, St Vincent's Hosp, Sydney, 3. School of Pharmacy, UQ, Brisbane, 4. Certara, Inc., Princeton, 5. Mark Wainwright Analytical Centre, UNSW, Sydney.
Presentation type Oral
Presenters Ranita Kirubakaran
Background. Numerous population pharmacokinetic (popPK) models of tacrolimus (TAC) in adult transplant recipients have been published. However, data on the accuracy of Bayesian forecasting with concomitant azole therapy or extrapolation to other transplant cohorts are scarce. Aims. To externally validate the predictive performances of relevant popPK models of TAC in adult heart transplant (HTX) recipients […]
Predictive performance of a Bayesian forecasting software for tacrolimus in adult heart transplant
January 6, 2019
Authors Ranita Kirubakaran (1,2), Sophie L Stocker (1,2), Richard O Day (1,2), Jane E Carland (1,2).
Affiliations 1. St Vincent's Clinical School, UNSW, Sydney, NSW, Australia, 2. Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst, NSW, Australia.
Presentation type Oral
Presenters Ranita Kirubakaran
Introduction: Previous clinical audit of tacrolimus (TAC) in 2017 heart transplant (HTx) recipients at St Vincent’s Hospital, Sydney (SVH) observed poor sampling time of TAC trough concentrations.Bayesian forecasting software may assist in the interpretation of TAC concentrations collected at any point in time. Aims: To evaluate the predictive performance of a Bayesian forecasting software, DoseMeRx® (Brisbane, Australia) in […]