Background/Objective: There is inconclusive evidence surrounding the pharmacokinetics (PK) of rivaroxaban in morbidly obese subjects with venous thromboembolism, which is associated with high rates of morbidity and mortality globally. The objective of the current study is to investigate the impact of obesity on rivaroxaban PK, using artificial intelligence-based computational methods. Methods: GastroPlus® was used to […]
Author: Orachid
Mechanistic Modeling of Intranasal Ketamine Pharmacokinetics in Pediatrics: A Physiological-based Pharmacokinetic (PBPK) Approach for Precision Dosing
Background/Objectives: Intravenous ketamine, though effective for pediatric sedation, poses logistical challenges and patient distress. Intranasal administration offers a noninvasive alternative with rapid onset, yet dosing variability in children remains poorly characterized. The objective of the study reported here is to develop a computational model predicting nasal ketamine pharmacokinetics in the pediatric population, enabling precision dosing […]