Introduction: Type 1 Cannabinoid Receptor (CB1) is the most abundant receptor in human brain and regulates multiple physiological activities via triggering downstream signalling network. CB1 internalisation is part of the signalling network, causing desensitization and this is a highly dynamic process. Orthosteric ligand (OL) could bind to endocannabinoids’ binding site and allosteric modulator (AM) could bind […]
