Michael Barras

  • Royal Brisbane & Women's Hospital

Author Archive | Michael Barras

The evaluation of an individualised dosing strategy derived from population PK modelling and simulation

Background:┬áRecently published enoxaparin dosing guidelines for obese and renally impaired patients are purported to increase the probability of achieving and maintaining anti-Xa (aXa) concentrations within the therapeutic range (TR) of 500-1000 IU/L. Exposure-response data indicate that concentrations greater than the TR increase the risk of bleeding, while concentrations less than the TR increase mortality. Aim:┬áTo […]

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