Introduction: Target-controlled infusion (TCI) models, such as Marsh and Schnider are commonly used for the induction and maintenance of propofol total intravenous anaesthesia (TIVA). However, substantial inter-individual variability remains in patient response, including time to loss and return of consciousness. Population pharmacokinetic (popPK) analyses require accurate dosing/input data to reliably characterise drug disposition. Problem: : […]
