Using a Bayesian Modelling Approach with Balanced Informative Prior to Develop a Optimal Paediatric Dosing Paradigm using Scarce PK Data

Background: The conventional approaches to analyse scarce paediatric PK data with rich adult data often result in the estimated central tendency of the paediatric PK parameters being over-influenced by the adult data. Aims: The purpose of this study is to develop a Bayesian modelling approach with balancing informative prior to adequately analyse the limited PK […]