Modelling and simulation of IV lidocaine and its metabolites in adult surgical patients.

Background: Perioperative IV lidocaine infusions show promise for pain reduction and enhanced postoperative recovery. However, a lack of definitive data regarding optimal dosing, safety, and efficacy has led to controversy and limited its adoption. Additionally, uncertainty surrounds the role of lidocaine’s major metabolites, monoethylglycinexylidide (MEGX) and glycinexylidide (GX), in its overall effects. This study used […]