Population pharmacokinetics of daptomycin in vancomycin-resistant Enterococcus bloodstream infections

Background: Vancomycin-resistant Enterococcus faecium (VREfm) bloodstream infections (BSIs) are challenging to manage, with limited treatment options available. Daptomycin, a cyclic lipopeptide antibiotic is a key treatment agent, however optimal dosing regimens are uncertain. Daptomycin is highly protein bound (~93%) and has been reported to have significant between patient variability, including based on sex. Aims: This […]