Author: Katie Owens

The pharmacokinetic profile of intravenous paracetamol in adult patients undergoing major abdominal surgery: A population analysis

Katie Owens, Natalie Medlicott, Philip Murphy, Julia Kennedy, Mathew Zacharias, Sree Chary, Neil Curran, Mark Thompson-Fawcett, David Reith
School of Pharmacy, University of Otago, University College Cork, Ireland, Dunedin Hospital, Dunedin School of Medicine, University of Otago

The aim of the present study was to determine the effect of major surgery on paracetamol glucuronidation and sulfation. 53 patients were given doses of either 1, 1.5 or 2 g of paracetamol by intravenous (IV) infusion. A combination of rich and sparse plasma and urine samples were collected over a 7 day period (Day […]

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The effect of surgery on the glucuronidation and sulphation of paracetamol

KH Owens (1), DM Reith (2), NJ Medlicott (1), M Zacharias (3), S Chary (1)
(1) School of Pharmacy , (2) Dunedin School of Medicine, University of Otago, (3) Dunedin Hospital Dunedin

Intravenous paracetamol is commonly used in the post operative period for the treatment of mild to moderate pain following surgery. The aim of the present study was to investigate the effect of major bowel surgery on paracetamol glucuronidation and sulphation. Patients were given 1 g intravenous paracetamol (10mg/mL) infused over 10 min on the morning […]

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