The aim of the present study was to determine the effect of major surgery on paracetamol glucuronidation and sulfation. 53 patients were given doses of either 1, 1.5 or 2 g of paracetamol by intravenous (IV) infusion. A combination of rich and sparse plasma and urine samples were collected over a 7 day period (Day […]
Katie Owens
- University of Otago
Author Archive | Katie Owens
The effect of surgery on the glucuronidation and sulphation of paracetamol
January 30, 2011
Authors KH Owens (1), DM Reith (2), NJ Medlicott (1), M Zacharias (3), S Chary (1)
Affiliations (1) School of Pharmacy , (2) Dunedin School of Medicine, University of Otago, (3) Dunedin Hospital Dunedin
Presentation type Poster
Intravenous paracetamol is commonly used in the post operative period for the treatment of mild to moderate pain following surgery. The aim of the present study was to investigate the effect of major bowel surgery on paracetamol glucuronidation and sulphation. Patients were given 1 g intravenous paracetamol (10mg/mL) infused over 10 min on the morning […]