Author: Katarina Vucicevic

The influence of biologically effective dose (BED) on the 131I therapy response in patients with benign thyroid disease – nonlinear mixed effect modelling approach

Valentina Topić Vučenović (1,2), Zvezdana Rajkovača (3), Dijana Jelić (4), Dragi Stanimirović (3), Momir Mikov (5), Branislava Miljković (2), Katarina Vučićević (2)
1. Department of Pharmacy, Faculty of Medicine, University of Banja Luka, Bosnia and Herzegovina; 2. Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade - Faculty of Pharmacy, Republic of Serbia; 3. Institute of Nuclear Medicine and Thyroid Gland Disease, University Clinical Centre of the Republic of Srpska, Bosnia and Herzegovina; 4. Chemistry Department, Faculty of Natural Sciences and Mathematics, University of Banja Luka, Bosnia and Herzegovina; 5. Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Novi Sad – Faculty of Medicine, Republic of Serbia.

Aim. The purpose of the study was to explore the influence of biologically effective dose (BED [Gy]), the administered radioactivity dose (Aa [MBq]), the total absorbed dose (ABD [Gy]), the maximum of absorbed dose-rate (MXR [Gy/h]) to radioactive iodine (131I) on the response in patients with benign thyroid disease. Materials and methods. Data from adult […]

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