Author: Kris Jamsen

A Regression Approach to Visual Predictive Checks for Population Pharmacokinetic and Pharmacodynamic Models

Kris Jamsen (1, 2), Kashyap Patel (1, 2), Keith Nieforth (1), Carl Kirkpatrick (2)
1. d3 Medicine, A Certara Company, 2. Centre for Medicine Use and Safety, Monash University

Objectives: To demonstrate how regression techniques can be used to perform visual predictive checks (VPCs) and prediction-corrected VPCs (pcVPCs) for population pharmacokinetic (PK) and pharmacodynamic (PD) models.  This approach negates the need for specification of intervals, or “bins”, of the independent variable. Methods: VPCs were derived using additive quantile regression (AQR). pcVPCs were generated by […]

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The effects of polypharmacy and Drug Burden Index on transitions in cognitive function and death: the CHAMP study

Kris M Jamsenn (1,2), Jenni Ilomäki (1), David Le Couteur (3,4,5), Robert G Cumming (3,4,6), J Simon Bell (1,2)
1. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Australia; 2. Cognitive Decline Partnership Centre, Hornsby Ku-ring-gai Hospital, Hornsby, NSW; 3. Sydney Medical School, University of Sydney, Sydney, NSW, Australia; 4. Centre for Education and Research on Ageing, Concord Hospital, Concord, NSW, Australia; 5. ANZAC Institute, Concord Hospital, Concord, NSW, Australia; 6. Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia

Background: Cognitive impairment is a disabling condition and is associated with mortality. Multiple medication use and the use of sedative and anticholinergic medications are associated with poor clinical outcomes including excess morbidity and cognitive impairment. Objective: To investigate the effects of multiple medication use and Drug Burden Index (DBI) on transitions in cognitive function and […]

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