Objectives: To demonstrate how regression techniques can be used to perform visual predictive checks (VPCs) and prediction-corrected VPCs (pcVPCs) for population pharmacokinetic (PK) and pharmacodynamic (PD) models. This approach negates the need for specification of intervals, or “bins”, of the independent variable. Methods: VPCs were derived using additive quantile regression (AQR). pcVPCs were generated by […]
Author: Kris Jamsen
The effects of polypharmacy and Drug Burden Index on transitions in cognitive function and death: the CHAMP study
Background: Cognitive impairment is a disabling condition and is associated with mortality. Multiple medication use and the use of sedative and anticholinergic medications are associated with poor clinical outcomes including excess morbidity and cognitive impairment. Objective: To investigate the effects of multiple medication use and Drug Burden Index (DBI) on transitions in cognitive function and […]