Introduction: Paracetamol toxicity is the leading cause of acute liver failure in many countries. The most commonly discussed mechanism for paracetamol poisoning is the production of the highly reactive toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). NAPQI can deplete liver glutathione (GSH) and bind with liver protein and cause liver injury with higher doses of paracetamol. Among […]
Jingyun
- University of Otago
Author Archive | Jingyun
A quantitative systems pharmacology model for glutathione depletion during paracetamol overdose
December 12, 2018
Authors Jingyun Li (1), Geoffrey K. Isbister (2), Stephen B. Duffull (1)
Affiliations 1. School of Pharmacy, University of Otago, Dunedin, New Zealand, 2. School of Medicine and Public Health, The University of Newcastle, Newcastle, Australia
Presentation type Oral
Presenters Jingyun Li
Introduction: Paracetamol toxicity is a common cause of acute liver failure in many countries. Most paracetamol is metabolised to the non-toxic sulfate and glucuronide conjugates. Only about 5% is oxidised to the highly reactive toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), which can be detoxified by hepatic glutathione(GSH). At higher doses of paracetamol, NAPQI depletes stores of both GSH and cysteine. […]