Author: Jingyun

Introduction: Paracetamol toxicity is the leading cause of acute liver failure in many countries. The most commonly discussed mechanism for paracetamol poisoning is the production of the highly reactive toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). NAPQI can deplete liver glutathione (GSH) and bind with liver protein and cause liver injury with higher doses of paracetamol. Among […]

Introduction: Paracetamol toxicity is a common cause of acute liver failure in many countries. Most paracetamol is metabolised to the non-toxic sulfate and glucuronide conjugates. Only about 5% is oxidised to the highly reactive toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), which can be detoxified by hepatic glutathione(GSH). At higher doses of paracetamol, NAPQI depletes stores of both GSH and cysteine. […]