Mechanism-based Pharmacodynamic (PD) Modeling of Phenotypic Tolerance in Pseudomonas aeruginosa for Ceftazidime

Background: Phenotypic tolerance describes the situation in which bacteria are resistant to antibiotics but are genotypically susceptible. Such tolerance may be important for optimal antibiotic therapy. Objectives: 1) To develop a mechanism-based PD model that describes the potential phenotypic tolerance of P. aeruginosa at high initial inocula (CFUo; CFU: colony forming units) to ceftazidime. 2) To propose strategies […]