A mathematical model for the effect of malaria on arginine catabolism in endothelial cells

Background: Malaria is an infectious disease caused by protozoan parasites from the genus Plasmodium. P. falciparum infects red blood cells (RBCs) which thus adhere to the microvascular endothelium. The accumulation of infected RBCs cause the reduction of oxygen resulting in impaired perfusion and, eventually, organ damage [1]. The characteristics of severe malaria are decreased nitric […]