Active or passive maternal smoking causes many adverse effects on fetuses. Pregnancy-related physiologically based pharmacokinetic (p-PBPK) models could help interpret nicotine and its major metabolite cotinine‘s absorption, disposition, metabolism, and excretion (ADME) in pregnant women. This talk presents a p-PBPK model and its simulations for nicotine and cotinine. The maternal-placental-fetal compartments of the p-PBPK model contain […]
hwe001
- University of Auckland, New Zealand
Dr Ho received PhD in Bioengineering from the University of Auckland in 2011. His research interests include mathematical modelling for physiological flows, physiologically based pharmacokinetics modelling, 3D visualisation of bio-structures, medical image computing and surgical simulations. He is the first or corresponding author of ~70 peer-reviewed international journal papers/book chapters, including the top journals in his research field.
Author Archive | hwe001
Extrapolating pharmacokinetic models from adults to neonates and infants: Case studies with paracetamol
The absorption, distribution, metabolism and excretion (ADME) of drugs in the human body may be quite different between adults and infants/neonates, since the enzymes involved in metabolic pathways exhibit distinct levels of activities at different ages. In the case of paracetamol, for example, neonates have a lower total clearance per kg bodyweight compared with adults, […]