Active or passive maternal smoking causes many adverse effects on fetuses. Pregnancy-related physiologically based pharmacokinetic (p-PBPK) models could help interpret nicotine and its major metabolite cotinine‘s absorption, disposition, metabolism, and excretion (ADME) in pregnant women. This talk presents a p-PBPK model and its simulations for nicotine and cotinine. The maternal-placental-fetal compartments of the p-PBPK model contain […]
Author: hwe001
Extrapolating pharmacokinetic models from adults to neonates and infants: Case studies with paracetamol
The absorption, distribution, metabolism and excretion (ADME) of drugs in the human body may be quite different between adults and infants/neonates, since the enzymes involved in metabolic pathways exhibit distinct levels of activities at different ages. In the case of paracetamol, for example, neonates have a lower total clearance per kg bodyweight compared with adults, […]