Background: Mechanism-based mathematical models (MBMs) address limitations of PK/PD indices, such as the time unbound antibiotic concentration exceeds the pathogen’s MIC (fT>MIC). Meropenem (MEM) is commonly used against Pseudomonas aeruginosa (PA) infections, however resistance mechanisms reduce its effectiveness. We developed a novel MBM to 1) characterise the full time-course of bacterial killing and resistance emergence in seven isogenic PA strains […]
