Background High-risk Pseudomonas aeruginosa ST235-clone causes endemics worldwide, is commonly multidrug-resistant and hypervirulent, and associated with high mortality rates. Therefore, innovative and model-informed treatment options, such as novel β-lactam combinations, are urgently needed. Aims The aim of this study was to 1) evaluate the effects of meropenem and ceftazidime/avibactam, in monotherapy and combinations, on bacterial […]
Author: Dominika Fuhs
Mechanism-based mathematical modelling predicts the impact of resistance mechanisms present in Pseudomonas aeruginosa on meropenem effectiveness
Background: Mechanism-based mathematical models (MBMs) address limitations of PK/PD indices, such as the time unbound antibiotic concentration exceeds the pathogen’s MIC (fT>MIC). Meropenem (MEM) is commonly used against Pseudomonas aeruginosa (PA) infections, however resistance mechanisms reduce its effectiveness. We developed a novel MBM to 1) characterise the full time-course of bacterial killing and resistance emergence in seven isogenic PA strains […]