Conor O’Hanlon

Abstracts

Population pharmacokinetics of milrinone in premature neonates to adolescents

Conor J O’Hanlon (1), Anita Sumpter (2), Jacqueline Hannam (1), Brian Anderson (2,3)
(1) Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand; (2) Department of Anaesthesia, Starship Children’s Hospital, Auckland, New Zealand; (3) Department of Anaesthesiology, University of Auckland, New Zealand.
January 20, 2023

Introduction: Milrinone is an inotrope and vasodilator used for prophylaxis or treatment of low cardiac output syndrome after weaning from cardiopulmonary bypass (CPB). It is renally eliminated and has an acceptable range of 100 – 300 μg/L, but weight-based dosing alone is associated with poor target attainment [1].Aims: To develop a population PK model for […]

Abstracts

Cefazolin pharmacokinetics and extent of device binding during cardiopulmonary bypass

Conor J O’Hanlon (1), Jacqueline A Hannam (1), Brian J Anderson (2,3), Mark Greaves (3), Nick HG Holford (1)
(1) Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand. (2) Department of Anaesthesiology, University of Auckland, Auckland, New Zealand. (3) Department of Anaesthesia, Starship Children’s Hospital, Auckland, New Zealand.
January 21, 2022February 21, 2022

Introduction: Cefazolin is administered routinely for antibiotic prophylaxis during cardiac surgery. However there is uncertainty in determining the correct dose due to the impact of critical illness and the cardiopulmonary bypass (CPB) machine on drug pharmacokinetics (PK). Aims: To quantify cefazolin adsorption to the CPB machine device and incorporate this into a population PK model […]

Abstracts

An ex vivo study measuring antibiotic adsorption to cardiopulmonary bypass circuitry

Conor O'Hanlon (1), Nick Holford (1), Jacqueline Hannam (1), Mark Greaves (2), Brian Anderson (2)
1. Department of Pharmacology and Clinical Pharmacology, University of Auckland, 2. Department of Anaesthesia, Auckland City Hospital
January 20, 2021January 23, 2021

Background: Cephazolin and vancomycin are commonly used for antibiotic prophylaxis during surgery supported by cardiopulmonary bypass (CPB). Antibiotic pharmacokinetics (PK) can be altered by CPB through haemodilution, haemofiltration, hypothermia and drug adsorption to the circuitry (1). Adsorption can contribute to decreased antibiotic concentrations with consequent reduced prophylactic effectiveness (2). Highly protein bound drugs like cephazolin […]