ISoP Lecture 2013: “Broadening the Impact” – Identifying Some Novel Clinical Applications of Pharmacometrics Research

The background, approach and challenges to conducting pharmacometrics research in four novel therapeutic scenarios are described all of which are currently being investigated by the presenter’s research team: “Therapeutic Hypothermia and Anticonvulsant Pharmacokinetics in Newborn Infants with Hypoxic Ischemic Encephalopathy HIE)”, “Melatonin Pharmacokinetics in Tetraplegia”, “Modeling Fetal Drug Exposure”, “A Thymine-Based PK Screening Test for […]

Population Pharmacokinetics of Oral and Intravenous Caffeine in Extremely Premature Neonates

Background: Apnea of prematurity (AP) is a potentially serious condition in >90% of extremely premature neonates. It is characterized by the cessation of airways movements for 15-20 seconds or more and, if left untreated, can have serious sequelae. Caffeine (citrate salt) is now the drug of choice for helping wean premature infants from mechanical ventilation, but […]