The background, approach and challenges to conducting pharmacometrics research in four novel therapeutic scenarios are described all of which are currently being investigated by the presenter’s research team: “Therapeutic Hypothermia and Anticonvulsant Pharmacokinetics in Newborn Infants with Hypoxic Ischemic Encephalopathy HIE)”, “Melatonin Pharmacokinetics in Tetraplegia”, “Modeling Fetal Drug Exposure”, “A Thymine-Based PK Screening Test for […]
Author: Bruce Charles
Population Pharmacokinetics of Oral and Intravenous Caffeine in Extremely Premature Neonates
Background: Apnea of prematurity (AP) is a potentially serious condition in >90% of extremely premature neonates. It is characterized by the cessation of airways movements for 15-20 seconds or more and, if left untreated, can have serious sequelae. Caffeine (citrate salt) is now the drug of choice for helping wean premature infants from mechanical ventilation, but […]