The design of a pharmacokinetic study of Intranasal Fentanyl

Objective:  To create a sampling schedule for a population pharmacokinetic study of Intranasal Fentanyl (INF) in paediatric patients presenting to the emergency department of a tertiary care hospital. Methods:   A search of the literature was conducted to determine reasonable assumptions regarding the underlying structural model, pharmacokinetic parameters and appropriate methods for scaling down values of […]