Appropriate antimicrobial therapy in neonates and babies is complicated by pharmacokinetic (PK) changes with age, body size and disease. Additionally we lack pharmacodynamic (PD) measures to gauge patient response. A correlation exists between elevated concentrations of procalcitonin (PCT) and infection +/- sepsis butmultiple other factors also contribute to PCT fluctuations (1, 2). For example, PCT […]

Jacqueline Hannam
- PAGANZ Secretary
- PAGANZ Inc Society Member
- University of Auckland
Author Archive | Jacqueline Hannam
Paracetamol and diclofenac additive effects after tonsillectomy
February 1, 2012
Authors Jacqueline A Hannam (1), Brian J Anderson (1), Nick HG Holford (1)
Affiliations (1) University of Auckland, New Zealand
Presentation type Oral
Presenters Jacqueline Hannam
Background: Paracetamol combined with diclofenac is commonly used to control postoperative pain in children. Diclofenac pharmacokinetics, and paracetamol pharmacokinetics (PK) and dynamics (PD) (analgesia) have been described with these drugs used separately (1, 2). A model for the combination of paracetamol with diclofenac would be useful for improving analgesia in children. Methods: A randomised, placebo […]