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Jacqueline Hannam

Author Archive | Jacqueline Hannam

A model for procalcitonin concentrations following birth in non infected preterm neonates

January 25, 2021

Authors Jacqueline A Hannam1,2, Brian J Anderson2, Nick HG Holford1
Affiliations 1Department of Pharmacology & Clinical Pharmacology, University of Auckland; 2 Department of Anaesthesiology, University of Auckland.
Presentation type Oral
Presenters Jacqui Hannam

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Background: Procalcitonin (PCT) may be used to monitor infection and guide antibiotic therapy (1). However its usefulness in neonates is hampered due to changes following birth and events such as surgery. Methods: PCT concentrations measured in 282 non-infected pre-term and term neonates (22 and 41 weeks gestation) were provided for analysis (2). A turnover model was […]

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Future work in Auckland: procalcitonin in healthy and infected neonates to inform PKPD disease progression modelling

January 15, 2019

Authors Jacqueline Hannam (1), Nicholas G. Holford (1), Brian J Anderson (2, 3)
Affiliations 1. Department of Pharmacology & Clinical Pharmacology, The University of Auckland, Auckland, New Zealand. 2. 1. Department of Anaesthesiology, The University of Auckland, Auckland, New Zealand. (3) Starship Children’s Hospital, Auckland District Health Board, Auckland, New Zealand.
Presentation type Oral
Presenters Jacqueline Hannam

Appropriate antimicrobial therapy in neonates and babies is complicated by pharmacokinetic (PK) changes with age, body size and disease. Additionally we lack pharmacodynamic (PD) measures to gauge patient response. A correlation exists between elevated concentrations of procalcitonin (PCT) and infection +/- sepsis butmultiple other factors also contribute to PCT fluctuations (1, 2). For example, PCT […]

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Paracetamol and diclofenac additive effects after tonsillectomy

February 1, 2012

Authors Jacqueline A Hannam (1), Brian J Anderson (1), Nick HG Holford (1)
Affiliations (1) University of Auckland, New Zealand
Presentation type Oral
Presenters Jacqueline Hannam

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Paracetamol and diclofenac additive effects after tonsillectomy

Background: Paracetamol combined with diclofenac is commonly used to control postoperative pain in children. Diclofenac pharmacokinetics, and paracetamol pharmacokinetics (PK) and dynamics (PD) (analgesia) have been described with these drugs used separately (1, 2). A model for the combination of paracetamol with diclofenac would be useful for improving analgesia in children. Methods: A randomised, placebo […]

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